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Bamboo Leaf-Like Micro-Nano Sheets Self-Assembled by Block Copolymers as Wafers for Cells

Articles

Journal/Conference:

MACROMOLECULAR BIOSCIENCE

Language:

English

Author:

Zhu Wen; Peng Bo; Wang Jing; Zhang Ke; Liu Lixin; Chen Yongming

Year:

2014

Volume:

14

Issue:

12

Pages:

1764-1770

Keywords:

block copolymers; crystallization; poly(epsilon-caprolactone); self-assembly

Bamboo leaf shaped poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO-b-PCL) sheets were prepared via crystallization-driven self-assembly. By selecting an appropriate mixed solvent, the polymer sheets, with a PCL single-crystal layer sandwiched by two PEO layers, were obtained efficiently. The morphology and structure of the sheets were characterized by microscopes and diffraction techniques. As a non-spherical model particle, endocytosis of the sheets was investigated on RAW 264.7, U937, HUVECs, HeLa, and 293T cells. The polymer sheets, just like wafers for cells, displayed a selective internalization to different cells, which showed a potential application in accurate cell targeting drug delivery and imaging.