International Bamboo and Rattan Organization

International Bamboo and Rattan Organization

Advanced search

-
Back

In Vitro Inhibition of the Transcription Factor NF-kappa B and Cyclooxygenase by Bamboo Extracts

Articles

Journal/Conference:

PHYTOTHERAPY RESEARCH

Language:

English

Author:

Van Hoyweghen Laura; De Bosscher Karolien; Haegeman Guy; Deforce Dieter

Experts:

Heyerick Arne

Year:

2014

Volume:

28

Issue:

2

Pages:

224-230

Keywords:

Bamboo leaves; traditional medicine; cyclooxygenase; NF-B; LC-MS; MS

Several bamboo species have been used in traditional medicine for the treatment of inflammatory conditions. The present study evaluates the in vitro anti-inflammatory properties of the traditionally used bamboo species Phyllostachys nigra (Lodd.) Munro and Sasa veitchii (Carr.) Rehder to explore their future research opportunities and therapeutic potential as anti-inflammatory agents. The extracts were evaluated for their potential inhibitory activity at the level of NF-B-induced gene expression and suppression of cyclooxygenase (COX)-1 and COX-2 enzyme activities, representative pharmacological targets for the anti-inflammatory action of glucocorticoids and non-steroidal anti-inflammatory drugs, respectively. The activity of P. nigra (Lodd.) Munro and S. veitchii (Carr.) Rehder was compared with bamboo species without traditional anti-inflammatory indications. High-performance liquid chromatography with diode-array detection and liquid chromatography-tandem mass spectrometry analyses were performed to phytochemically characterize the extracts. P. nigra (Lodd.) Munro leaf extract potently inhibited NF-B-induced gene expression, while S. veitchii (Carr.) Rehder leaf extract exerted a selective COX-2 inhibition. The crude extracts consistently showed a more potent bioactivity than the solid phase extraction fractions. P. nigra (Lodd.) Munro and S. veitchii (Carr.) Rehder both exert anti-inflammatory properties, but act via a different molecular mechanism. Copyright (c) 2013 John Wiley & Sons, Ltd.